Ascent Research support various immortalized cells including spontaneous immortalized cell lines, and immortalized primary cells. Immortalized cells, or immortalized cell lines, are cells escaping replicate senescence through the spontaneous accumulation or artificial introduction of genetic/epigenetic mutations to inactivate growth arrest pathways, or activate telomerase (TERT), or bypass senescence and apoptosis checkpoints. Spontaneous immortalization requires continuous long-term culture, typically achieved through a process called serial transfer to select immortal clones. Other immortalization methods involve with transfection or transduction. Viral oncogenes (e.g. SV40 large T antigen, HPV E6/E7, Adenovirus E1A/E1B) are introduced to inactivate or degrade p53 and Rb, allowing bypass of senescence; or TERT is overexpressed to prevents telomere shortening, allowing cells to divide indefinitely.
Our immortalized cells include various cell type from multiple species. If you would like to immortalize your own primary cells, please view our Cell Immortralization Service or directly contact us. Our expert team will assist you for your specific research needs.
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The immortalized rat pulmonary artery smooth muscle cell is the cell line of muscle cells derived from the lung. It…
Cat. No. ARI0196
The immortalized rat pulmonary microvascular cell is the cell line of microvascular cells derived from the lung. It is cultured…
Cat. No. ARI0197
The immortalized rat pulmonary microvascular endothelial cell is the cell line of endothelial cells derived from the lung. It is…
Cat. No. ARI0198
The immortalized rat uterine smooth muscle cell is the cell line of muscle cells derived from the uterus. It is…
Cat. No. ARI0200
The immortalized sheep endometrial epithelial cell is the cell line of endothelial cells derived from the uterus (endometrium). It is…
Cat. No. ARI0201
The immortalized sheep rumen epithelial cell is the cell line of epithelial cells derived from the rumen. It is cultured…
Cat. No. ARI0202
The immortalized sheep testis Leydig cell is the cell line of Leydig cells derived from the testis. It is cultured…
Cat. No. ARI0203
4E11 is a hybridoma cell line, established from the fusion of spleen cells with NS-1 myeloma cells.
Cat. No. ARI0204
9.3F10 is a hybridoma cell line, established from the fusion of spleen cells with?P3U1 myeloma cells.?The spleen cells were isolated…
Cat. No. ARI0205
BB7.1 is a hybridoma cell line, established from the fusion of spleen cells with NS-1 myeloma cells. The spleen cells…
Cat. No. ARI0206
BB7.7 is a hybridoma cell line, established from the fusion of spleen cells with NS-1 myeloma cells. The spleen cells…
Cat. No. ARI0207
BBM.1 is a hybridoma cell line, established from the fusion of spleen cells with P3X63Ag8 myeloma cells. The spleen cells…
Cat. No. ARI0208
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