Ascent Research support various immortalized cells including spontaneous immortalized cell lines, and immortalized primary cells. Immortalized cells, or immortalized cell lines, are cells escaping replicate senescence through the spontaneous accumulation or artificial introduction of genetic/epigenetic mutations to inactivate growth arrest pathways, or activate telomerase (TERT), or bypass senescence and apoptosis checkpoints. Spontaneous immortalization requires continuous long-term culture, typically achieved through a process called serial transfer to select immortal clones. Other immortalization methods involve with transfection or transduction. Viral oncogenes (e.g. SV40 large T antigen, HPV E6/E7, Adenovirus E1A/E1B) are introduced to inactivate or degrade p53 and Rb, allowing bypass of senescence; or TERT is overexpressed to prevents telomere shortening, allowing cells to divide indefinitely.
Our immortalized cells include various cell type from multiple species. If you would like to immortalize your own primary cells, please view our Cell Immortralization Service or directly contact us. Our expert team will assist you for your specific research needs.
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The CHO-K1 cell line is a subclone of the CHO cell line, which was derived from a biopsy of an…
Cat. No. ARI0250
The hTERT-HPNE cell line is an hTERT-immortalized epithelial cell line derived from the human pancreatic duct. It was established by…
Cat. No. ARI0244
GES-1 is a human gastric epithelial cell line, established by infecting primary epithelial cells with SV40. These cells exhibit a…
Cat. No. ARI0242
LX-2 cell line is human hepatic stellate cell line derived by spontaneously immortalization at low serum condition, used as a…
Cat. No. ARI0245
BEAS-2B is an immortalized human bronchial epithelial cell line, established by infecting the normal human bronchial epithelial cells with an…
Cat. No. ARI0241
MC3T3-E1 Subclone 24 cell line is a subclone of MC3T3-E1 cell line, a human osteoblast cell line. A series of…
Cat. No. ARI0246
3T3-Swiss albino is a fibroblast cell line derived from the embryo of disaggregated Swiss albino mouse. In the early report,…
Cat. No. ARI0240
MDCK cell line is a cancine kidney epithelial cell line, isolated from normal kidney tissue from a normal, adult, female…
Cat. No. ARI0247
BHK-21 is a fibroblast cell line derived from baby hamster kidney of 1-day-old hamster. The BHK-21 cells are shown to…
Cat. No. ARI0239
NE-4C is a neuroepithelial cell line, established from cerebral vesicles of 9-day-old mouse embryos lacking functional p53 gene. NE-4C cells…
Cat. No. ARI0248
Vero is an epithelial cell line derived from the kidney of Africa green monkey. The vero cell line is used…
Cat. No. ARI0249
MT-2 cell line was derived from the co-cultivation of normal human umbilical cord leukocytes of a healthy donor with diseased…
Cat. No. ARI0238
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