Ascent Research support various immortalized cells including spontaneous immortalized cell lines, and immortalized primary cells. Immortalized cells, or immortalized cell lines, are cells escaping replicate senescence through the spontaneous accumulation or artificial introduction of genetic/epigenetic mutations to inactivate growth arrest pathways, or activate telomerase (TERT), or bypass senescence and apoptosis checkpoints. Spontaneous immortalization requires continuous long-term culture, typically achieved through a process called serial transfer to select immortal clones. Other immortalization methods involve with transfection or transduction. Viral oncogenes (e.g. SV40 large T antigen, HPV E6/E7, Adenovirus E1A/E1B) are introduced to inactivate or degrade p53 and Rb, allowing bypass of senescence; or TERT is overexpressed to prevents telomere shortening, allowing cells to divide indefinitely.
Our immortalized cells include various cell type from multiple species. If you would like to immortalize your own primary cells, please view our Cell Immortralization Service or directly contact us. Our expert team will assist you for your specific research needs.
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IGG-6A6 is a hybridoma cell line, established from the fusion of spleen cells with Sp2/0 myeloma cells. The spleen cells…
Cat. No. ARI0209
L243 is a hybridoma cell line, established from the fusion of spleen cells with NS-1 myeloma cells. The spleen cells…
Cat. No. ARI0210
OKT 11 is a hybridoma cell line, established from the fusion of spleen cells with P3X63Ag8.U1 myeloma cells. The spleen…
Cat. No. ARI0211
145-2C11 is a hybridoma cell line, established from the fusion of spleen cells with Sp2/0-Ag14 myeloma cells. The spleen cells…
Cat. No. ARI0212
IVA12 is a hybridoma cell line, established from the fusion of spleen cells with Sp2/0-Ag14 myeloma cells. The spleen cells…
Cat. No. ARI0213
ME 1 is a hybridoma cell line, established from the fusion of spleen cells with NS-1 myeloma cells. The spleen…
Cat. No. ARI0214
MR1 is a hybridoma cell line, established from the fusion of spleen cells with NS-1 myeloma cells. The spleen cells…
Cat. No. ARI0215
W6/32 is a hybridoma cell line, established from the fusion of spleen cells with P3X63Ag8 myeloma cells. The spleen cells…
Cat. No. ARI0217
VSC4.1 is a hybridoma cell line derived from the fusion of?embryonic rat ventral spinal cord neurons?with?mouse N18TG2 neuroblastoma cells.
Cat. No. ARI0219
NG108-15 is established by the fusion of N18TG2 neuroblastoma cells with rat C6-BU-1 glioma cells.
Cat. No. ARI0220
EA.hy926 is a hybrid cell line derived from the fusion of A549/8 with human umbilical vein endothelial cells.
Cat. No. ARI0221
TE4 is a hybridoma cell line, established from the fusion of spleen cells with P3X63Ag8 myeloma cells. The spleen cells…
Cat. No. ARI0222
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