Ascent Research support various immortalized cells including spontaneous immortalized cell lines, and immortalized primary cells. Immortalized cells, or immortalized cell lines, are cells escaping replicate senescence through the spontaneous accumulation or artificial introduction of genetic/epigenetic mutations to inactivate growth arrest pathways, or activate telomerase (TERT), or bypass senescence and apoptosis checkpoints. Spontaneous immortalization requires continuous long-term culture, typically achieved through a process called serial transfer to select immortal clones. Other immortalization methods involve with transfection or transduction. Viral oncogenes (e.g. SV40 large T antigen, HPV E6/E7, Adenovirus E1A/E1B) are introduced to inactivate or degrade p53 and Rb, allowing bypass of senescence; or TERT is overexpressed to prevents telomere shortening, allowing cells to divide indefinitely.
Our immortalized cells include various cell type from multiple species. If you would like to immortalize your own primary cells, please view our Cell Immortralization Service or directly contact us. Our expert team will assist you for your specific research needs.
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C17.2 is an immortalized cell line of neural progenitor cells transformed with v-Myc.
Cat. No. ARI0022
C2C12 is a spontaneously immortalized cell line of myoblast, derived from the skeletal muscle. Synonym: C2c12; C2-C12; C12
Cat. No. ARI0023
C3H/10T1/2 clone 8 is a spontaneously immortalized cell line, derived from the embryo.
Cat. No. ARI0024
C8-D1A is a spontaneously immortalized cell line of astrocytes, derived from the cerebellum.
Cat. No. ARI0025
CATH.a is an immortalized cell line of neurons transformed by Simian virus 40 (SV40).
Cat. No. ARI0026
CFSC-8B is a spontaneously immortalized cell line of hepatic stellate cells, derived from the liver.
Cat. No. ARI0027
The COS-1 cell line is derived from the CV-1 cells, an African green monkey kidney cell line. These cells are…
Cat. No. ARI0028
The COS-7 cell line is derived from the CV-1, a fibroblast-like cell line of the African green monkey kidney. These…
Cat. No. ARI0029
CTLL-2 is an immortalized cell line of T cell.
Cat. No. ARI0030
CTX-TNA2 is an immortalized cell line of astrocytes transformed by Simian virus 40 (SV40).
Cat. No. ARI0031
DC2.4 is an immortalized cell line of dendritic cells transformed by Recombinant retrovirus J2.
Cat. No. ARI0032
DI TNC1 is an immortalized cell line of diencephalon, immortalized by Simian virus 40 (SV40).
Cat. No. ARI0033
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