The integumentary system is the outer layer of the body, mainly consisting of skin, nails, and hair, with the supporting tissues: such as glands, nerves, and blood vessels. As the outer layer, the integumentary system, especially skin, is typically referred to as the first barrier of defense against bacteria, viruses, and other microbes from external environment. It protects the body from UV radiation, regulate temperature, assistant to detect sensations.
Investigations on integumentary system cells involve the understanding of skin diseases, mechanisms of wound healing and regeneration, assessment of skin toxicity for pharmaceuticals and cosmetics, mechanisms of skin aging and pigmentation, etc.
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