Cat. No. ARC1037
Cancer (Tumor) Cell Lines
Homo sapiens (Human)
Ovary
Serous adenocarcinoma
OVKATE is a human ovarian cancer cell line established from the primary ovarian tumor of a 40-year-old female with serous papillary adenocarcinoma. At the time of establishment, OVKATE cells were tumorigenic in nude mice after both Intraperitoneal and subcutaneous (s.c.) transplantation. However, more recent studies have shown that OVKATE forms only after subcutaneous implantation[1]. The cells harbor an R282W mutation in the TP53 gene, resulting in a loss of TP53 function. OVKATE cells have been also reported to be resistant to platinum-based agents[2].
OVKATE is a significant cancer cell model of primary high-grade serous adenocarcinoma (HGSOC). The generation of xenograft models OVKATE enables a deeper understanding and preclinical drug development for ovarian cancer research.
[1] A. K. Mitra et al., “In vivo tumor growth of high-grade serous ovarian cancer cell lines,” Gynecol. Oncol., vol. 138, no. 2, pp. 372–377, Aug. 2015, doi: 10.1016/j.ygyno.2015.05.040.
[2] S. Yamaguchi, Y. Maida, M. Yasukawa, T. Kato, M. Yoshida, and K. Masutomi, “...... Targets Human Telomerase Reverse Transcriptase in Ovarian Cancer Cells,” PLoS ONE, vol. 9, no. 11, p. e112438, Nov. 2014, doi: 10.1371/journal.pone.0112438.
Cryopreserved in vials and shipped on dry ice
Characteristics
Sex of Donor
Female
Age
40 years
Derived From Site
In situ; Ovary
Morphology
Epithelial-like
Growth Mode
Adherent
Culture Conditions
Temperature
37℃
Atmosphere
5% CO2
Quality Control
Sterility testing
The bacterial, yeast, and fungi are not detected in these cells by daily monitor.
Mycoplasma testing
Negative for mycoplasma through PCR analysis
Disclaimer
Intended Use
This product is intended for laboratory in vitro use only. lt is not intended for diagnostic, therapeutic, or clinical applications.
Disclaimer
Ascent Research endeavors to provide accurate and up-to-date product information. However, no warranties or representations are made regarding its completeness or reliability. References to scientific literature and patents are for informational purposes only, and the customer assumes sole responsibility for verifying their accuracy.
By accepting this product, the customer acknowledges and agrees to assume all risks associated with its receipt, handling, storage, disposal, and use, including compliance with all applicable safety and environmental regulations and precautions. Relevant laws, regulations, and ethical guidelines must be followed in conducting any research, modifications, or derivatives derived from this product.
This product is provided "AS IS", and except as expressly stated herein, Ascent Research disclaims all other warranties, express or implied. Under no circumstances shall Ascent Research, its affiliates, or representatives be liable for indirect, incidental, consequential, or punitive damages arising from the use of this material. While Ascent Research employs rigorous quality control measures, we shall not be held responsible for damages resulting from misidentification or misinterpretation of the provided materials.
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