Ascent Research support various immortalized cells including spontaneous immortalized cell lines, and immortalized primary cells. Immortalized cells, or immortalized cell lines, are cells escaping replicate senescence through the spontaneous accumulation or artificial introduction of genetic/epigenetic mutations to inactivate growth arrest pathways, or activate telomerase (TERT), or bypass senescence and apoptosis checkpoints. Spontaneous immortalization requires continuous long-term culture, typically achieved through a process called serial transfer to select immortal clones. Other immortalization methods involve with transfection or transduction. Viral oncogenes (e.g. SV40 large T antigen, HPV E6/E7, Adenovirus E1A/E1B) are introduced to inactivate or degrade p53 and Rb, allowing bypass of senescence; or TERT is overexpressed to prevents telomere shortening, allowing cells to divide indefinitely.
Our immortalized cells include various cell type from multiple species. If you would like to immortalize your own primary cells, please view our Cell Immortralization Service or directly contact us. Our expert team will assist you for your specific research needs.
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ARPE-19/HPV-16 is an immortalized cell line of epithelial cells transformed by Human papillomavirus type 16 (HPV16).
Cat. No. ARI0010
The B95-8 cell line is a lymphoblastoid line derived from the marmoset leukocytes, immortalized by Epstein-Barr virus (EBV), which is…
Cat. No. ARI0011
Ba/F3 is a pro-B cell line. It was confirmed to show a lymphatic background. Its growth is IL-3 dependent. Synonym:…
Cat. No. ARI0012
BALB/3T3 clone A31 is a spontaneously immortalized cell line of fibroblast, derived from the embryo. Synonym: BALB/c 3T3 clone A31;…
Cat. No. ARI0013
bEnd.3 is an immortalized cell line of endothelial cells transformed by Murine polyomavirus (strain A2) (MPyV). Synonym: b.End3; bEnd3; BEND-3;…
Cat. No. ARI0014
bEnd.5 is an immortalized cell line of endothelial cells transformed by Murine polyomavirus (strain A2) (MPyV).
Cat. No. ARI0015
BNL CL.2 is a spontaneously immortalized cell line, derived from the embryonic liver.
Cat. No. ARI0016
BPH-1 is an immortalized cell line of the prostate, immortalized by Simian virus 40 (SV40).
Cat. No. ARI0017
BRL is a spontaneously immortalized cell line, derived from the liver.
Cat. No. ARI0018
BRL-3A is a spontaneously immortalized cell line of fibroblast, derived from the liver.
Cat. No. ARI0019
The BV-2 cell line is a murine microglia cell line derived from C57BL/6 mice, transformed using a v-raf/v-myc carrying retrovirus…
Cat. No. ARI0020
C166 is a spontaneously immortalized cell line, derived from the yolk sac.
Cat. No. ARI0021
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