Canine brain microvascular endothelial cells are primary cells isolated from the brain microvasculature of Beagle dog. These cells are supplied cryopreserved at an early passage stage to help retain key physiological properties relevant to in vitro research.
Within the central nervous system, the brain microvasculature forms the vascular interface of cerebral capillaries and is a core structural component of the blood-brain barrier. Brain microvascular endothelial cells line these vessels and help regulate exchange between the circulation and neural tissue.
In their native tissue environment, these endothelial cells establish a selective barrier that controls the movement of nutrients, ions, and metabolites across brain capillaries. They also support cerebrovascular homeostasis through interactions with pericytes, astrocytes, and other components of the neurovascular unit, while participating in inflammatory signaling pathways relevant to vascular function and disease.
These cells are well suited for blood-brain barrier modeling, neurovascular biology studies, drug transport and permeability assays, and cerebrovascular inflammation research. For additional product or donor information, please contact Ascent Research.
