Research on the Human Calvarial Osteoblasts is essential to the study of osteoporosis, osteogenesis imperfecta, Paget's disease of bone, bone metastasis (e.g., breast/prostate cancer), and medication-related osteonecrosis of the jaw (MRONJ). Bones are hard organs in the body, composed of minerals (mainly calcium and phosphorus) and collagen. They provide the main structural support for the body, protect internal organs, facilitate movement, and produce blood cells. The human body has a total of 206 bones, forming the skeletal system, connected by joints and ligaments. The Human Calvarial Osteoblasts are to be used with Human Calvarial Osteoblast Medium (Cat. No. ACM0154). This product is intended for laboratory in vitro use only. It is not intended for diagnostic, therapeutic, or clinical applications.