Human small intestine microvascular endothelial cells are primary cells isolated from the microvasculature of the small intestine within the digestive system. These cells are derived from fresh human tissue and are preserved by cryogenic storage at an early passage stage to help retain relevant physiological properties in culture.
The small intestine is responsible for digestion, nutrient absorption, and maintenance of a selective barrier between the intestinal lumen and underlying tissues. Within this environment, microvascular endothelial cells line the inner surface of small blood vessels and support exchange between circulating blood and the surrounding intestinal tissue.
In the intestinal microenvironment, these endothelial cells regulate vascular permeability and mediate the transport of gases, nutrients, and metabolites. They also contribute to angiogenic processes and participate in leukocyte trafficking during immune responses, reflecting their central role in vascular homeostasis, tissue remodeling, and communication with neighboring epithelial, stromal, and immune cells.
These cells are well suited for intestinal microvascular biology studies, angiogenesis and endothelial barrier assays, inflammation and leukocyte adhesion research, and drug transport, toxicity, and vascular response studies. For additional product or donor information, please contact Ascent Research.
