LX-2

Product Type:
Immortalized Cell Line
Species:
Homo sapiens (Human)
Tissue Source:
Liver

Datasheet

LX-2 cell line is human hepatic stellate cell line derived by spontaneously immortalization at low serum condition, used as a model for studying liver fibrosis. It retains the characteristic retinoid phenotype of stellate cells and expresses classic markers, including α-smooth muscle actin, vimentin, and glial fibrillary acidic protein. LX-2 cells express crucial receptors involved in fibrogenesis, such as PDGFR-β, Discoidin Domain Receptor 2, and the leptin receptor, alongside major matrix remodeling proteins like MMP-2, TIMP-2, and MT1-MMM (with reduced TIMP-1). Functionally, LX-2 cells proliferate in response to PDGF stimulation, upregulate procollagen expression upon TGF-β1 treatment, and are highly transfectable. Gene expression profiling demonstrates a striking 98.7% similarity to primary human hepatic stellate cells, including the expression of neuronal genes, confirming its close resemblance to the in vivo phenotype.

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$1,400.00

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Cryopreserved in vials and shipped on dry ice

Disclaimer:

For Research Use Only

Characteristics

Cell Type

Epithelial cell line

Sex of Donor

Male

Age

Unknown

Derived From Site

Liver

Morphology

Epithelial-like

Growth Mode

Adherent

Immortalizaion Method

Spontaneously
Culture Conditions

Temperature

37°C

Atmosphere

5% CO₂
Quality Control

Sterility testing

The bacterial, yeast, and fungi are not detected in these cells by daily monitor.

Mycoplasma testing

Negative for mycoplasma through PCR analysis
Disclaimer

Intended Use

This product is intended for laboratory in vitro use only. lt is not intended for diagnostic, therapeutic, or clinical applications.

Disclaimer

Ascent Research endeavors to provide accurate and up-to-date product information. However, no warranties or representations are made regarding its completeness or reliability. References to scientific literature and patents are for informational purposes only, and the customer assumes sole responsibility for verifying their accuracy.

By accepting this product, the customer acknowledges and agrees to assume all risks associated with its receipt, handling, storage, disposal, and use, including compliance with all applicable safety and environmental regulations and precautions. Relevant laws, regulations, and ethical guidelines must be followed in conducting any research, modifications, or derivatives derived from this product.

This product is provided "AS IS", and except as expressly stated herein, Ascent Research disclaims all other warranties, express or implied. Under no circumstances shall Ascent Research, its affiliates, or representatives be liable for indirect, incidental, consequential, or punitive damages arising from the use of this material. While Ascent Research employs rigorous quality control measures, we shall not be held responsible for damages resulting from misidentification or misinterpretation of the provided materials.